Smoke too much weed? Experts say the results could be sickening

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By Pauline Bartolone
Kaiser Health News

For 17 years, Chalfonte LeNee Queen suffered periodic episodes of violent retching and abdominal pain that would knock her off her feet for days, sometimes leaving her writhing on the floor in pain. 

“I’ve screamed out for death,” said Queen, 48, who lives in San Diego. “I’ve cried out for my mom who’s been dead for 20 years, mentally not realizing she can’t come to me.” 

Queen lost a modeling job after being mistaken for an alcoholic. She racked up tens of thousands of dollars in medical bills, and her nausea interrupted her sex life. Towards the end of her illness, Queen, who stands 5-foot-9, weighed in at a frail 109 pounds. 

Throughout the nearly two decades of pain, vomiting and mental fog, she visited the hospital about three times a year, but doctors never got to the bottom of what was ailing her. By 2016, she thought she was dying, that she “must have some sort of cancer or something they can’t detect,” Queen said. 

But she didn’t have cancer. She had an obscure syndrome called cannabinoid hyperemesis syndrome, a condition only recently acknowledged by the medical community. It affects a small population — namely, a subset of marijuana users who smoke multiple times a day for months, years or even decades. 

There’s no hard data on the prevalence of the illness. But in California and Colorado, which have loosened marijuana laws in recent years, emergency physicians say they’re seeing it more often. One study in Colorado suggests there may be a link. 

Dr. Aimee Moulin, an emergency room physician at UC Davis Medical Center in Sacramento, said she has seen a rise in the number of cases since California voters legalized recreational marijuana last November, and she expects to see another increase after commercial sales are permitted starting in January. 

Doctors say it’s difficult to treat the condition. There is no cure other than to quit using marijuana, and many patients are skeptical that cannabis is making them sick, so they keep using it and their vomiting episodes continue. 

Doctors can do little to relieve the symptoms, since traditional anti-nausea medications often don’t work and there are no pills to prevent the onset of an episode. Patients may need intravenous hydration and hospital stays until the symptoms subside. 

“That’s really frustrating as an emergency physician,” said Moulin. “I really like to make people feel better.” 

Diagnosing the syndrome can also be frustrating — and expensive. There is no blood test to link the stomach ailment with marijuana use, so physicians often order pricey cat scans and lab tests to rule out other medical problems.

Cannabinoid hyperemesis syndrome was first documented in Australia in 2004. Physicians have historically misdiagnosed it as the more generic cyclic vomiting syndrome, which has no identifiable cause or, as in Queen’s case, acute intermittent porphyria (AIP). 

vomiting
Dr. John Coburn, an emergency physician at Kaiser Permanente in Sacramento, Calif., says his department sees the cannabis-related vomiting illness every day. (Pauline Bartolone/California Healthline)

“Five years ago, this wasn’t something that [doctors] had on their radar,” said Dr. Kennon Heard, an emergency physician at the University of Colorado in Aurora, who co-authored the Colorado study showing a possible tie between the liberalization of marijuana and a surge of the vomiting illness. “We’re at least making the diagnosis more now.” 

One surefire sign of the illness is when patients find relief in hot showers and baths. Queen said she would vomit repeatedly unless she was in a hot shower — so she’d stay in there for hours. Toxicologists say the heat may distract the brain from pain receptors in the abdomen but, like the syndrome itself, that phenomenon is not well understood. 

The exact cause of the condition is still a mystery. Toxicologists say the chemical compounds in marijuana may throw off the normal function of the body’s cannabinoid receptors, which help regulate the nervous system. 

Some people may be genetically predisposed to the syndrome, or marijuana’s potency or chemical makeup may have changed over time, said Dr. Craig Smollin, medical director of the San Francisco division of the California Poison Control System, who also works as an emergency physician at Zuckerberg San Francisco General Hospital. 

The vomiting link to cannabis is counterintuitive to many, because of its widely known reputation as an anti-nausea remedy for cancer patients. 

“A lot of times, people just don’t believe you,” said Dr. John Coburn, an emergency physician at Kaiser Permanente in South Sacramento. Even after being told that quitting may help, some patients will visit the hospital multiple times before they stop smoking marijuana, Coburn said. “I can’t really tell you why. I mean, why do people ride motorcycles without helmets on?”

For on the effects of long-term pot use, go to California Healthline.  

“This story was produced by Kaiser Health News, which publishes California Healthline, an editorially independent service of the California Health Care Foundation.” 

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